Archive
Volume 2, 2024
Editorial
Hiding in Plain Sight: FDA-Approved Cholesterol Drug Ezetimibe as a Treatment for Alzheimer’sVera Gorbunova and Andrei Seluanov
Research Paper
Senescence Signatures Predict Hospitalization Risk and Severity in COVID-19 PatientsSeodhna M. Lynch, Thomas McLarnon, Eamonn Cooper, Darren McDaid, Guangran Guo, Joseph McLaughlin, Victoria E. McGilligan, Steven Watterson, Priyank Shukla, Shu-Dong Zhang, Magda Bucholc, Andrew English, Laura Freeman, Rachelle E. Irwin, Aaron Peace, Maurice O’Kane, Martin Kelly, Manav Bhavsar, Elaine K. Murray, David S. Gibson, Colum P. Walsh, Anthony J. Bjourson, and Taranjit Singh Rai
Research Paper
Pharmacology of Aging: Drosophila as a Tool to Validate Drug Targets for Healthy LifespanEliano dos Santos and Helena M. Cochemé
Research Paper
Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Arterial Dysfunction in MiceAbigail G. Longtine, Nathan T. Greenberg, Antonio Gonzalez, Alexandra Lindquist, Nicholas S. VanDongen, Sophia A. Mahoney, Gibraan Rahman, Zachary S. Clayton, Brian P. Ziemba, Katelyn R. Ludwig, Michael E. Widlansky, Rob Knight, Douglas R. Seals, Vienna E. Brunt
Research Paper
Aging Clocks, Entropy, and the Challenge of Age ReversalAndrei E. Tarkhov, Kirill A. Denisov, Peter O. Fedichev
Research Paper
Low-Dose Naltrexone as a Potential Healthspan-Enhancing Intervention in a Normative Aging Cohort: Changes in Quality of Life and Immune Health MetricsGirish Harinath, Andy Nyquist, Maartje Wouters, Anar Isman, Brandon Verkennes, Sajad Zalzala
Research Paper
Exploring the Stability of Genomic Imprinting and X-Chromosome Inactivation in the Aged BrainSamantha Mancino, Janith Seneviratne, Annalisa Mupo, Felix Krueger, David Oxley, Melanie A. Eckersley-Maslin, and Simão Teixeira da Rocha
Research Paper
Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase InteractionAkshatha Ganne, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Ramani Atluri, Sonu Pahal, Joseph J. Asante, Corey Nagel, Srikanth Vallurupalli, Robert J. Shmookler Reis, Srinivas Ayyadevara
Research Paper
Characterization of Naked Mole-Rat Mesenchymal Stromal Cells: Comparison with Long- and Short-Lived MammalsStephan Emmrich, Alexandre Trapp, Adit Ganguly, Ali S. Biashad, Yulia Ablaeva, Michael G. Drage, Masaki Takasugi, Andrei Seluanov, Vera Gorbunova
Perspective
Nutrition Interventions as Geroprotectors: Design and Interpretation of Early-Stage Clinical Trial of StrawberriesJamie N. Justice
Research Paper
An Enterobacteriaceae Bloom in Aging Animals is Restrained by the Gut MicrobiomeRebecca Choi, Rahul Bodkhe, Barbara Pees, Dan Kim, Maureen Berg, David Monnin, Juhyun Cho, Vivek Narayan, Ethan Deller, Cathy Savage-Dunn, Michael Shapira
Research Paper
Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish RetinaGregory J. Konar, Zachary Flickinger, Shivani Sharma, Kyle T. Vallone, Charles E. Lyon Jr., Claire Doshier, Audrey Lingan, William Lyon, James G. Patton
Research Paper
Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 MimeticsEdward P. Fielder, Abbas Ishaq, Evon Low, Joseph A. Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki, Satomi Miwa
Research Paper
GCN2 Mediates Access to Stored Amino Acids for Somatic Maintenance during Drosophila AgingJoshua N. Johnstone, Christen K. Mirth, Travis K. Johnson, Ralf B. Schittenhelm, Matthew D. W. Piper
Research Paper
Early-Onset Hearing Loss in Mouse Models of Alzheimer’s Disease and Increased DNA Damage in the CochleaJae-Hyeon Park, Burcin Duan Sahbaz, Komal Pekhale, Xixia Chu, Mustafa N. Okur, Mhamed Grati, Kevin Isgrig, Wade Chien, Elena Chrysostomou, Lauren Sullivan, Deborah L. Croteau, Uri Manor, Vilhelm A. Bohr
Research Paper
Genetic and Pharmacological Inhibition of PAPP-A Reduces Bleomycin-Induced Pulmonary Fibrosis in Aged Mice via Reduced IGF SignalingLaurie K. Bale, Sally A. West, Claus Oxvig, Kristian S. Andersen, Anja C. Roden, Andrew J. Haak, Cheryl A. Conover
Research Paper
High-Dose Polyphenol-Rich Nutrition Improves Lipid and Inflammation Profiles and Can Trigger Apoptotic Signaling in Healthy Older Adults (the ErdBEHR Study)Alexander Hartmann, Riccardo Secci Juliane Mensch Kathrin Jäger Elisabeth Steinhagen-Thiessen Israel Barrantes Daniel Palmer, Axel Kowald, Rico Schwarz, Burkhard Hinz, Daniela Weber, Tilman Grune, Verena Heck, Matthias Strauss, Marc Pignitter, Patricia Huebbe, Gerald Rimbach, Henrik Rudolf, Michael Walter, Georg Fuellen
Research Paper
Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine RestrictionJason D. Plummer, Mark C. Horowitz, Jay E. Johnson
Volume 1, 2023
Research Paper
Early and Late Chaperone Intervention Therapy Boosts XBP1s and ADAM10, Restores Proteostasis, and Rescues Learning in Alzheimer’s Disease MiceJennifer M. Hafycz, Ewa Strus, Kamalini Sengupta, Nirinjini Naidoo
Research Paper
Embryogenesis of Longer-Lived Mammalian Species Occurs in a More Severe Hypoxic-Hypercapnic EnvironmentKhachik K. Muradian, Vadim E. Fraifeld
Research Paper
Failure to Repair Endogenous DNA Damage in β-Cells Causes Adult-Onset Diabetes in MiceMatthew J. Yousefzadeh, Ana P. Huerta Guevara, Andrea C. Postmus, Rafael R. Flores, Tokio Sano, Angelika Jurdzinski, Luise Angelini, Sara J. McGowan, Ryan D. O’Kelly, Erin A. Wade, Lisa V. Gonzalez-Espada, Danielle Henessy-Wack, Shannon Howard, Tania A. Rozgaja, Christy E. Trussoni, Nicholas F. LaRusso, Bart J. L. Eggen, Johan W. Jonker, Paul D. Robbins, Laura J. Niedernhofer, Janine K. Kruit
Research Paper
Cellular Senescence Exacerbates Features of Aging in the EyesKoji Kitazawa, Kohsaku Numa, Sandip Kumar Patel, Christina D. King, Akifumi Matsumoto, Chie Sotozono, Pierre-Yves Desprez, Birgit Schilling, and Judith Campisi
Research Paper
Stochasticity Explains Nongenetic Inheritance of Lifespan and Apparent Trade-Offs between Reproduction and AgingElizabeth D. Drake, and Mirre J. P. Simons
Research Paper
Aging, Parkinson’s Disease, and Models: What Are the Challenges?Emily Rocha, Manish Chamoli, Shankar J. Chinta, Julie K. Andersen, Ruby Wallis, Erwan Bezard, Matt Goldberg, Tim Greenamyre, Warren Hirst, We-Li Kuan, Deniz Kirik, Laura Niedernhofer, Irit Rappley, Shalini Padmanabhan, Louis-Eric Trudeau, Maria Spillantini, Simon Scott, Lorenz Studer, Ilaria Bellantuono, and Heather Mortiboys
Research Paper
STAT1 Drives the Interferon-Like Response and Aging Hallmarks in ProgeriaRafael Cancado de Faria, Elena V. Shashkova, Colin Flaveny, Angel Baldan,Kyle S. McCommis, and Susana Gonzalo
Research Paper
Senolytics Reduce Endothelial Cell DNA Damage and Telomere Dysfunction Despite Reductions in Telomere LengthSamuel I. Bloom, Eric Tuday, Md Torikul Islam, Venkateswara R. Gogulamudi, Lisa A. Lesniewski, and Anthony J. Donato
Research Paper
Analysis of Somatic Mutations in Senescent Cells Using Single-Cell Whole-Genome SequencingLei Zhang, Marco De Cecco, Moonsook Lee, Xiaoxiao Hao, Alexander Y. Maslov, Cristina Montagna, Judith Campisi, Xiao Dong, John M. Sedivy, and Jan Vijg
Research Paper
Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular SenescenceShane A. Evans, Yee Voan Teo, Samuel J. Hinthorn, Kelly Clark, Takahiro Ito, John M. Sedivy, Nicola Neretti
Review Article
Aging Rate Indicators: Speedometers for Aging Research in MiceRichard A. Miller, Xinna Li, and Gonzalo Garcia
Full Article | PDF | Erratum
Research Paper
FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in miceMariah F. Calubag, Ismail Ademi, Chung-Yang Yeh, Reji Babygirija, Heidi H. Pak, Alyssa M. Bhoopat, Ildiko Kasza, Cara L. Green, Michelle M. Sonsalla, Dudley W. Lamming
Meeting Report
Biology of Stress Responses in AgingManolis Maragkakis, Sulochan Malla, Maria Hatzoglou, Aleksandra Trifunovic, Adam B. Glick, Toren Finkel, Valter D. Longo, Susmita Kaushik, Pura Muñoz-Cánoves, Gordon J. Lithgow, Nirinjini Naidoo, Lauren N. Booth, Matthew J. Payea, Allison B. Herman, Rafael de Cabo, David M. Wilson 3rd, Luigi Ferrucci, and Myriam Gorospe
Editorial
How much should we fast?A new study by the Fontana group suggests that intermittent fasting may be too mild for humans.
Vera Gorbunova
Research Paper
When a Calorie Is Not a Calorie: Metabolic and Molecular Effects of Intermittent Fasting in Humans; Exploratory Outcomes of a Randomized Clinical TrialValeria Tosti, Ruteja A Barve, Beatrice Bertozzi, Nicola Veronese, Francesco Spelta, Edda Cava, Mark P. Mattson, Laura Piccio, Dayna S Early, Richard D Head, Luigi Fontana